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For U.S. Residents Only

Otrexup Co-Pay Assistance Program

To receive co-pay assistance of up to $250 for each prescription filled, please accurately complete the form below. You will receive a unique co-pay card via email entered below. Show this co-pay card to the pharmacist.
Terms and conditions apply. Applicable to eligible patients with commercial insurance.


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To ensure each patient is benefiting from the Otrexup Co-Pay Assistance Program, Assertio would like to notify you about updates to the program by email.
By providing your email address above, you consent to receiving these updates.

Please see Important Safety Information when the coupon is printed.

Eligibility Restrictions: Offer only valid for patients with commercial prescription insurance. Maximum benefit of up to $250 for each prescription filled. Offer not valid for prescriptions reimbursed under any federal or state healthcare program, including Medicare, Medicaid, or any state medical assistance programs. Offer void where prohibited by law, taxed, or restricted. Offer only valid in the USA. Otter Pharmaceuticals reserves the right to rescind, revoke, or amend this offer at any time without notice. By using this co-pay assistance card, you demonstrate that you understand and agree to comply with the terms and conditions of this offer as put forth on this co-pay assistance card.



OTREXUP can cause serious side effects that can lead to death, including:

1. Organ system toxicity. People who use methotrexate for the treatment of cancer, psoriasis, or rheumatoid arthritis, have an increased risk of death from organ toxicity. Types of organ toxicity can include:

  • gastrointestinal
  • bone marrow
  • liver
  • immune system
  • nerve
  • lung
  • kidneys
  • skin

Your doctor will do blood tests and other types of tests before you take and while you are taking OTREXUP to check for signs and symptoms of organ toxicity. Call your doctor right away if you have any of the following symptoms of organ toxicity:

  • vomiting
  • diarrhea
  • mouth sores
  • fever
  • confusion
  • weakness
  • temporary blindness
  • seizures
  • headache
  • neck stiffness
  • paralysis
  • irritability
  • sleepiness
  • problems with coordination
  • dry cough
  • trouble breathing
  • severe skin rash
  • back pain

2. Women who are pregnant are at increased risk for death of the baby and birth defects. Women who are pregnant or who plan to become pregnant must not take OTREXUP. A pregnancy test should be performed before starting OTREXUP. Contraception should be used by both females and males while taking OTREXUP. Pregnancy should be avoided if either partner is receiving OTREXUP:

  • for a minimum of 3 months after treatment with OTREXUP for males.
  • during and for 6 months after treatment with OTREXUP for females.


OTREXUP is a single-dose auto-injector containing a prescription medicine, methotrexate. Methotrexate is used to:

  • Treat certain adults with severe, active rheumatoid arthritis (RA), and children with active polyarticular juvenile idiopathic arthritis (pJIA), after treatment with other medicines including non-steroidal anti-inflammatory drugs (NSAIDs) have been used and did not work well.
  • Control the symptoms of severe, resistant, disabling psoriasis in adults when other types of treatment have been used and did not work well.

OTREXUP should not be used for the treatment of cancer.
OTREXUP should not be used for the treatment of children with psoriasis.


Do not use OTREXUP if you:

  • Are pregnant or planning to become pregnant. See “What is the most important information I should know about OTREXUP?”
  • Are breastfeeding; OTREXUP can pass into your breast milk and may harm your baby.
  • Have alcohol problems (alcoholism)
  • Have liver problems
  • Have problems fighting infection (immunodeficiency syndrome)
  • Have been told you have (or think you have) a blood disorder such as low levels of white blood cells, red blood cells (anemia), or platelets
  • Have had an allergy to methotrexate or any of the ingredients in OTREXUP. See the Prescribing Information for a list of ingredients in OTREXUP.

Talk to your doctor before taking this medicine if you have any of these conditions.


Before you take OTREXUP, tell your doctor if you have any other medical conditions.
Tell your doctor about all of the medicines you take, including prescription, over-the-counter medicines, vitamins, and herbal supplements. OTREXUP may affect how other medicines work, and other medicines may affect how OTREXUP works causing side effects. Ask your doctor or pharmacist for a list of medicines if you are not sure.
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.


  • Read the Instructions for Use that come with OTREXUP.
  • Take OTREXUP exactly as your doctor tells you to take it.
  • Inject OTREXUP only 1 time each week. Do not take OTREXUP every day. Taking OTREXUP every day may cause death from toxicity.
  • Your doctor will show you or your caregiver how to inject OTREXUP. You should not inject OTREXUP until you have been trained on the right way to use it.
  • Check OTREXUP before you inject it. OTREXUP should be yellow in color and should not have any lumps or particles in it.
  • OTREXUP should be injected in the stomach (abdomen) or thigh.
  • Do not inject OTREXUP within 2 inches of the belly button (navel).
  • Do not inject OTREXUP in the arms or any other areas of the body.
  • Do not inject OTREXUP in areas where the skin is tender, bruised, red, scaly, hard, or has scars or stretch marks.
  • If you are not sure if OTREXUP was injected, or if you have a hard time giving the injection, do not inject another dose. Call your pharmacist or doctor right away.
  • If you inject too much OTREXUP, call your doctor or go to the nearest hospital emergency room right away.


  • Do not drink alcohol while taking OTREXUP. Drinking alcohol can increase your chances of getting serious side effects.
  • OTREXUP can cause dizziness and tiredness. Do not drive a car, operate machinery, or do anything that needs you to be alert until you know how OTREXUP affects you.
  • Certain vaccinations should be avoided while taking OTREXUP. Talk to your doctor before you or members of your household receive any vaccines.


OTREXUP may cause serious side effects, including:

  • Fertility problems. Methotrexate, the active ingredient in OTREXUP, may affect your ability to have a baby. Males may have a decreased sperm count, and females may have changes to their menstrual cycle. This can happen while taking OTREXUP and for a short period of time after you stop.
  • Certain cancers. Some people who have taken methotrexate have had a certain type of cancer called Non-Hodgkin’s lymphoma and other tumors. Your doctor may tell you to stop taking OTREXUP if this happens.
  • Tissue and bone problems. Taking methotrexate while having radiation therapy may increase the risk of your tissue or bone not receiving enough blood. This may lead to death of the tissue or bone.

Common side effects of OTREXUP include:

  • nausea
  • stomach pain
  • indigestion (dyspepsia)
  • mouth sores
  • rash
  • stuffy or runny nose and sore throat
  • diarrhea
  • abnormal liver function tests
  • vomiting
  • headache
  • bronchitis
  • low red, white, and platelet cell count
  • hair loss
  • dizziness
  • sensitivity to light
  • burning skin lesions
  • lung problems

Tell your doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of OTREXUP. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information, including Boxed Warning and Patient Information, at www.otrexup.com/PI.